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. 2004 Jul 15;114(2):172–181. doi: 10.1172/JCI20641

Figure 2.

Figure 2

(A) Representative aortic wall sections from mice aged 12 months, stained with H&E. NonTg is the nontransgenic control, Tg(WT) is from the strain expressing WT FBN1, and Tg(mut3) is from the strain with the highest expression of C1663R-mutant FBN1. Magnification, ×10 (top) and ×40 (bottom). In the low-power views, the adjacent pulmonary artery is visible. No differences were detected. (B) Representative radiographs taken of mice at 1 year of age. Overgrowth of the ribs and kyphoscoliosis are evident in the C1039G heterozygote (C1039G/+) mice (bottom), without discernible bony abnormalities in the Tg(mut3) mice, in comparison with nonTg control mice.