Figure 3.

STAT3 signaling inhibition decreased migration and invasion, and increased the apoptosis in AdCC cell line SACC-83. A: Scratch assay shows treatment with S3I-201 24 hours significantly decrease the mobility of SACC-83 cell line; and transwell assay shows the migration and invasion ability of SACC-83 were impaired when treated with S3I-201 compared with control group (Quantification of cell numbers with ImageJ “cell counter” module, Mean ± SD; ***P<0.001, student t-test with GraphPad Prism 5.0). B: Annexin V/PI staining showed S3I-201 treatment (100 uM and 200 uM) notably increased the apoptosis cells compared with the control group SACC-83.