Table 3.

Relationship between rs2380205, rs2981579 and breast cancer risk (age adjusted)

SNP ID	Model	Genotype	Control	Case	Without adjustment		With adjustment
					OR (95% CI)	p-valuea	OR (95% CI)	p-valueb
rs2380205	Codominant	C/C	164 (83.2%)	132 (73.3%)	1.00	0.039	1.00	0.055
		T/C	32 (16.2%)	44 (24.4%)	1.69 (1.02-2.82)		1.69 (1.02-2.82)
		T/T	1 (0.5%)	4 (2.2%)	5.19 (0.57-47.34)		5.19 (0.57-47.34)
	Dominant	C/C	164 (83.2%)	132 (73.3%)	1.00	0.021	1.00	0.034*
		T/C-T/T	33 (16.8%)	48 (26.7%)	1.80 (1.09-2.96)		1.72 (1.04-2.86)
	Recessive	C/C-T/C	196 (99.5%)	176 (97.8%)	1.00	0.120	1.00	0.120
		T/T	1 (0.5%)	4 (2.2%)	4.68 (0.51-42.49)		4.99 (0.53-47.41)
	Over-dominant	C/C-T/T	165 (83.8%)	136 (75.6%)	1.00	0.052	1.00	0.082
		T/C	32 (16.2%)	44 (24.4%)	1.65 (0.99-2.75)		1.58 (0.94-2.65)
	Log-additive	---	---	---	1.79 (1.12-2.84)	0.012*	1.73 (1.08-2.76)	0.020*
rs2981579	Codominant	T/T	56 (28.6%)	55 (30.4%)	1.00	0.120	1	0.120
		C/T	92 (46.9%)	96 (53%)	1.07 (0.67-1.71)		1.09 (0.68-1.76)
		C/C	48 (24.5%)	30 (16.6%)	0.62 (0.34-1.12)		0.62 (0.34-1.13)
	Dominant	T/T	56 (28.6%)	55 (30.4%)	1.00	0.690	1	0.740
		C/T-C/C	140 (71.4%)	126 (69.6%)	0.91 (0.59-1.42)		0.93 (0.59-1.45)
	Recessive	T/T-C/T	148 (75.5%)	151 (83.4%)	1.00	0.043*	1	0.042*
		C/C	48 (24.5%)	30 (16.6%)	0.59 (0.35-0.99)		0.59 (0.35-0.99)
	Over-dominant	T/T-C/C	104 (53.1%)	85 (47%)	1.00	0.210	1	0.180
		C/T	92 (46.9%)	96 (53%)	1.30 (0.87-1.95)		1.33 (0.88-2.00)
	Log-additive	---	---	---	0.81 (0.61-1.08)	0.160	0.81 (0.61-1.09)	0.170

^* p value ≤ 0.05 indicates statistical significance;

Abbreviations: OR, odd ratio; CI, confidence interval;

^a p values were calculated from two-sided chi-square tests or Fisher’s exact tests for either genotype distribution.

^b p values were calculated by unconditional logistic regression adjusted for age, menopausal state and body mass index.