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. 2004 Jul 15;114(2):240–249. doi: 10.1172/JCI20964

Figure 3.

Figure 3

Increased glucose tolerance but normal insulin sensitivity in PpargP465L/+ mice. (A) Plasma glucose and insulin levels during the IPGTT in 14- to 16-week-old male mice fed regular chow (left panels; n = 15–16) or a high-fat diet (right panels; n = 7–11). Open squares, wild-type; filled squares, PpargP465L/+. *P < 0.05 versus wild-type. (B) IPITTs of 14- to 16-week-old female mice fed regular chow (left panel; n = 7–8) or a high-fat diet (right panel; n = 6–7). Open squares, wild-type; filled squares, PpargP465L/+. Data are expressed as the percentage of the plasma glucose before insulin injection. (C) Whole-body metabolic parameters during the hyperinsulinemic-euglycemic clamp experiment. Steady-state glucose infusion rates (top left) and insulin-stimulated whole-body glucose turnover rates (top right) were obtained for 10- to 12-week-old male mice fed regular chow (RC; n = 5) or a high-fat diet (HF; n = 5–8). White bars, wild-type; black bars, Pparg465L/+. *P < 0.05 for diet effect. Basal (bottom left) and clamped (bottom right) rates of HGP in wild-type (white bars) and Pparg465L/+ (black bars) mice fed regular chow (RC; n = 5) or a high-fat diet (HF; n = 5–8). (D) Morphometric analysis of pancreatic islets. Mean islet area (left), pancreatic endocrine mass (middle), and islet number (right) were measured in sections from 14- to 16-week-old male mice fed regular chow (RC; n = 4) or a high-fat diet (HF; n = 4). White bars, wild-type; black bars, Pparg465L/+. *P < 0.05 and **P < 0.001 compared with wild-type littermates.