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. Author manuscript; available in PMC: 2016 May 5.
Published in final edited form as: Circulation. 2015 Mar 9;131(18):1555–1565. doi: 10.1161/CIRCULATIONAHA.114.013395

Figure 2.

Figure 2

Col4a1 mutation causes small vessel disease, hemorrhagic stroke and macro-angiopathy. (A) Col4a1+/Δex41 mice have porencephaly (penetrance: 80%) and intracerebral hemorrhages (penetrance: 100%) quantified using Prussian blue staining of serial coronal brain sections (scale bar: 1 mm). Data are reported as mean ± standard deviation. (B) Macro-angiopathy with vessel wall thickening, fibrosis and thrombosis advanced with age. Trichrome staining shows collagen deposition (blue) and fibrin accumulation (red) in affected blood vessels (scale bar: 100 μm). No Col4a1+/+ mice had porencephaly, intracerebral hemorrhage or macro-angiopathy (n=32).