. Author manuscript; available in PMC: 2015 Jul 9.

Published in final edited form as: Chem Biol Drug Des. 2014 May 12;84(2):158–168. doi: 10.1111/cbdd.12315

Table 2.

Comparison of NF54 and C9 susceptibility to the selected compounds. EC₅₀ values obtained from treating the wild type (NF54) and ΔPF3D7_1305500 (C9) parasites were compared using the Mann-Whitney test (α= 0.05). Compounds 5333073, 533730 and 579624 show NF54 to have significantly greater susceptibility (p< 0.05). This suggests that C9 parasites may have a slight advantage when not expressing the predicted target.

Compound ID	EC₅₀ NF54 (nM)	EC₅₀C9 (nM)	p
390097	340.2±53.6	248.9±33.7	0.1124
524725	503.1±36.5	248.4±62	0.0240
533073	471.9±37.4	1227.3±86.3	0.0013
533730	196.3±113.8	510.9±51.6	0.0073
525841	186.1±33.8	224.7±48.1	0.5467
579624	136±33.1	584±39.86	0.0010
585222	378.8±97.7	339.3±28	0.7070