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. Author manuscript; available in PMC: 2015 Jul 9.
Published in final edited form as: Curr Opin Biotechnol. 2010 Dec;21(6):834–842. doi: 10.1016/j.copbio.2010.09.018

Figure 1.

Figure 1

Structures of bryostatins “0”-20 (“bryostatin 0” is the hypothetical precursor to all the known bryostatins). Bryostatins which contain octa-2,4-dienoate moieties (in blue) are found only in the Deep B. neritina sibling species, whereas Shallow B. neritina contains bryostatins with other kinds of esterifications (in green). The oxygen groups highlighted in red represent the pharmacophoric elements involved in binding to PKC.