Table 2.
Significant differences between brain responses to an auditory 2-back task performed under blue light exposure and in darkness.
| Side | X, Y, Z | Z | Pcorrected Value* |
|
|---|---|---|---|---|
| Blue light > Darkness | ||||
| Ventrolateral prefrontal/frontopolar cortex | R | 28 52 6 | 4.72 | 0.032 |
| Ventrolateral prefrontal cortex (VLPFC) [a,b,c] | R # | 58 38 0 | 5.32 | 0.002 |
| R | 54 44 14 | 5.05 | 0.007 | |
| L | −56 30 14 | 4.61 | 0.049 | |
| Medial prefrontal cortex (MPFC) [d,e,f,g] | L | −12 60 −2 | 6.88 | < 0.001 |
| R | 10 54 18 | 6.19 | < 0.001 | |
| L | −12 50 30 | 6.05 | <0.001 | |
| R | 18 40 36 | 5.22 | 0.003 | |
| R | 18 54 0 | 4.76 | 0.026 | |
| R | 16 38 50 | 4.74 | 0.029 | |
| L | −18 56 16 | 4.71 | 0.033 | |
| Precuneus (PREC) [h] | R # | 8 −74 58 | 6.59 | < 0.001 |
| Calcarine sulcus (CALC) [i] | R | 10 −82 −4 | 7.73 | < 0.001 |
| Superior occipital gyrus (SOG) [j] | L # | −18 −98 −4 | 7.71 | < 0.001 |
| Inferior occipital gyrus (IOG) [k] | R # | 32 −80 −22 | 5.03 | < 0.008 |
| Anterior cingulate cortex (ACC) [l] | R | 10 38 10 | 4.78 | 0.024 |
| Thalamus (pulvinar) (PULV) [m] | L | −10 −20 12 | 4.64 | 0.044 |
| Darkness > Blue light | ||||
| No significant voxel | ||||
Letters between [] correspond to letters of figure 3.
*
p-values corrected for multiple comparisons over the entire brain volume (Family Wise Error approach).
#
in these areas, an additional analyses showed cluster size of the significant difference was slightly reduced after applying an exclusive mask (p=0.05 uncorrected for multiple comparisons) for the brain response to the task blocks performed in complete darkness. All other clusters remained unaffected after mask application, supporting that blue light induces the significant recruitment of additional brain regions.