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. 2015 Feb 1;4(1):164–174. doi: 10.1089/biores.2014.0057

FIG. 6.

FIG. 6.

Histological observation at 8 weeks of GAM transplantation to cranial bone defect. (A) Gross appearance of created cranial defect with 9 mm of diameter. (B,C) Representative images of HE staining of specimens in GFP, BMP4, and Runx2 groups, respectively. New bone tissues were recognized ubiquitously in BMP4 (C) and Runx2 (D) groups, while bone formation was not found in the defect area of the GFP group (B). Scale bar is 50 μm. Black dotted line indicates boundary of the host and defect area; asterisk, host bone; and black arrow, area of newly formed bone.