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. 2015 Jan 1;4(1):97–108. doi: 10.1089/biores.2014.0035

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© Rani Ojha et al. 2015; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 3. — Proposed model for the role of autophagy in cancer stem cells. Tumor consists of a heterogeneous cell population composed of clones from dividing tumor cells and a few tumor initiating cells or cancer stem cells (CSCs). Conventional therapies like radiotherapy and cytotoxic chemotherapy kill the dividing cells, but the tumor-initiating CSCs remain unaffected via autophagy-mediated cell survival mechanism. Therefore, targeting autophagy in CSCs may help to overcome the resistance and relapse of tumor.