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. 2015 Jan 1;4(1):39–53. doi: 10.1089/biores.2014.0055

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© Daniela Zwolanek et al. 2015; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 6. — Model for MSC adhesion to articular cartilage lesions. MSC are able to bind to collagen I in bone and to collagen II in cartilage in full-thickness cartilage defects (dashed line) via collagen-binding β1 integrins. In addition, MSC interact via RGD-binding integrins with fibronectin, a major matrix protein present in bone and cartilage.