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. 2015 Jan 1;4(1):65–74. doi: 10.1089/biores.2014.0034

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© Amanda Clark et al. 2015; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 6. — Representative histological images of (A) normal proximal tibial growth plate and proximal tibiae following treatment of defects with (B) fat implant, (C) blank scaffold, (D) IGF-loaded scaffold, and (E) cell-seeded, IGF-I-loaded scaffold. For images (B–E), the defects were on the medial (left) side, and the native growth plate is on the lateral (right) side. The black circle indicates an area of bone formed within the defect; the black arrow indicates a wide region of newly formed cartilage; red arrows indicate isolated areas of cartilage; and the yellow circle indicates a large, dense area of cartilage.