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. 2015 May 11;125(6):2473–2483. doi: 10.1172/JCI74159

Figure 8. Inhibition of Snail1 impacts expression of junctional components and reduces GBS virulence in zebrafish larvae.

Figure 8

Transgenic zebrafish expressing an inducible dominant-negative snai1a, Tg(HSP:dn-snai1a), upregulated occludin, E-cadherin, and claudin 5 following heat shock (HS) (n = 9) when compared with controls with no heat shock (no HS) (n = 4) 6 hours after heat shock (A–C). Kaplan-Meier survival curve of WT or Tg(HSP:dn-snai1a) transgenic zebrafish following heat shock and GBS challenge (n = at least 10/group). Transgenic zebrafish exhibited significantly lower mortality rates following GBS challenge compared with those of WT zebrafish (D). Data represent 3 independent experiments combined. Student’s t and log-rank tests were used to determine significance. *P < 0.05; **P < 0.01.