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. 2015 May 11;125(6):2497–2509. doi: 10.1172/JCI75438

Figure 1. miR-26a expression is reduced in obese mice and humans.

Figure 1

(A) Expression of miR-26a in livers of WT lean and ob/ob mice (n = 4–6). (B) Expression of miR-26a in livers of WT DIO mice fed a CD or a HFD (n = 5). (C) QRT-PCR analysis of human miR-26a expression in livers of lean (n = 5) and obese (n = 28, BMI > 25) individuals. (D) Correlation between hepatic miR-26a levels and BMI in a human cohort (n = 33). (E) Correlation between hepatic miR-26a levels and HOMA-IR in a human cohort (n = 33). miR-26a expression is normalized to 5S rRNA in mice and RNU24 in humans. Data are shown as mean ± SEM. *P < 0.05; **P < 0.01, 2-tailed Student’s t test.