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. 2015 Apr 27;125(6):2293–2306. doi: 10.1172/JCI75836

Figure 2. Allelic Gls reduction slows early tumor progression.

Figure 2

(A) Representative CT scans (for complete set, see Supplemental Figure 2) for LAP/MYC:Gls+/+, LAP/MYC:Gls+/–, and wild-type mice at 7 weeks of age. (B) Representative whole livers for LAP/MYC:Gls+/+, LAP/MYC:Gls+/–, and wild-type mice at 7 weeks of age. (C) Surrogate CT scan–based abdominal sizes in LAP/MYC:Gls+/+, LAP/MYC:Gls+/–, and wild-type mice at 7 weeks of age. (D) Kaplan-Meier plot of survival of LAP/MYC:Gls+/– mice (n = 11) compared with LAP/MYC:Gls+/+ mice (n = 19). P = 0.12. (E) Relative Gls mRNA expression in normal-appearing liver or liver tumors obtained from Gls homozygous (Gls+/+, blue) or heterozygous (Gls+/–, red) LAP/MYC mice (n = 3, each group). Values are shown as mean ± SD. Student’s t test was used.