Figure 5.

Remote guidance of the magnetic nanoconstructs and cooperative accumulation. a, Schematic of the parallel plate flow chamber apparatus used for testing the guidance of the magnetic nanoconstructs under controlled biophysical conditions. The static magnet was placed underneath the chamber, on the side and the nanoconstruct solution was infused via a syringe pump through the inlet bore. b, The variation of the longitudinal and transversal components of the nanoconstruct velocity, v_x and v_y, normalized with the chamber height h and wall shear rate S; and of the angle θ between the flow direction and the particle trajectory with the separation distance from the magnet. (black diamonds are for the SiMPs; triangles are for the DPNs) c, Image of a dark corona originating from the progressive accumulation of nanoconstructs around the magnet. d, Bright field microscopy images of SiMP nanoconstructs depositing on the bottom of the parallel plate flow chamber (S = 15⁻¹ sec). f, Fluorescent microscopy images of DPN nanoconstructs depositing on the bottom of the parallel plate flow chamber (S = 15⁻¹ sec). e,g, Four representative nanoconstruct clusters are identified for the SiMPs and DPNs by dashed circles and their relative area variation ΔA% is plotted over time.