Figure 1.
Association between increase in mammographic percent density and increase in serum level of progestogen from baseline to follow-up (at 12 months) among women randomized to estrogen+progestin therapy (CEE+MPA cyclic, CEE+MPA continuous, or CEE+MP) in the PEPI-MDS. Model parameter estimates and p-values were obtained from linear regression models adjusted for baseline mammographic density, age, BMI, race, smoking, physical activity, alcohol drinking, parity, E1S level at follow-up, and change in BMI. Abbreviations: CEE, conjugated equine estrogens; MPA, medroxyprogesterone acetate; MP, micronized progesterone.