Table 2.
Hematology, female, Phase B.
| Group no. | Animal no. | WBC (×109/L) | RBC (×1012/L) | HGB (g/L) | HCT (%) | MCV (fL) | MCH (pg) | MCHC (g/L) | PLT (×109/L) | RET (%) | RET (×109 cells/L) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Control/♀ | 21001 | 4.2 | 10.19 | 147 | 49 | 48.1 | 14.4 | 300 | 1094 | 5.32 | 541.9 |
| 0 mg/kg | 21002 | 3.56 | 10.2 | 149 | 49.5 | 48.6 | 14.6 | 300 | 797 | 5.55 | 565.8 |
| 21003 | 3.18 | 10.03 | 146 | 48.2 | 48 | 14.6 | 304 | 742 | 6.27 | 629.4 | |
| Mean | 3.65 | 10.14 | 147 | 48.9 | 48.2 | 14.5 | 301 | 878 | 5.71 | 579 | |
| SD | 0.52 | 0.1 | 2 | 0.7 | 0.3 | 0.1 | 2 | 189 | 0.5 | 45.2 | |
| Change (fold) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Inauhzin-C | 22001 | 4.01 | 8.96 | 136 | 43.9 | 49 | 15.2 | 310 | 1139 | 6.02 | 539.1 |
| Low/♀ | 22002 | 4.23 | 9.92 | 143 | 47.8 | 48.2 | 14.5 | 300 | 955 | 5.07 | 503.2 |
| 30 mg/kg | 22003 | 3.65 | 9.07 | 132 | 43.7 | 48.2 | 14.5 | 301 | 675 | 7.34 | 665.8 |
| Mean | 3.96 | 9.32 | 137 | 45.1 | 48.5 | 14.7 | 304 | 923 | 6.14 | 569.4 | |
| SD | 0.29 | 0.53 | 6 | 2.3 | 0.5 | 0.4 | 6 | 234 | 1.14 | 85.4 | |
| Change (fold) | 1.1 | 0.9 | 0.9 | 0.9 | 1 | 1 | 1 | 1.1 | 1.1 | 1 | |
| Inauhzin-C | 23001 | 3.19 | 9.35 | 141 | 46.7 | 50 | 15.1 | 302 | 665 | 6.11 | 570.9 |
| Mid/♀ | 23002 | 5.23 | 8.97 | 140 | 46.8 | 52.2 | 15.6 | 300 | 1182 | 10.08 | 904.3 |
| 60 mg/kg | 23003 | 3.26 | 8.97 | 134 | 44.7 | 49.8 | 15 | 301 | 1235 | 6.92 | 621.4 |
| Mean | 3.89 | 9.1 | 138 | 46.1 | 50.7 | 15.2 | 301 | 1027 | 7.7 | 698.9 | |
| SD | 1.16 | 0.22 | 4 | 1.2 | 1.3 | 0.3 | 1 | 315 | 2.1 | 179.7 | |
| Change (fold) | 1.1 | 0.9 | 0.9 | 0.9 | 1.1 | 1 | 1 | 1.2 | 1.3 | 1.2 | |
| Inauhzin-C | 24001 | 2.15 | 8.84 | 133 | 42.9 | 48.5 | 15 | 309 | 776 | 6.57 | 580.8 |
| High/♀ | 24002 | 6.28 | 8.69 | 131 | 43.5 | 50 | 15.1 | 302 | 1164 | 7.41 | 649.5 |
| 120 mg/kg | 24003 | 2.32 | 9.61 | 146 | 48.6 | 50.5 | 15.2 | 302 | 1062 | 7.54 | 724.1 |
| Mean | 3.58 | 9.05 | 137 | 45 | 49.7 | 15.1 | 304 | 1001 | 7.17 | 651.5 | |
| SD | 2.34 | 0.49 | 8 | 3.1 | 1 | 0.1 | 4 | 201 | 0.53 | 71.7 | |
| Change (fold) | 1 | 0.9 | 0.9 | 0.9 | 1 | 1 | 1 | 1.1 | 1.3 | 1.1 | |
| Group no. | Animal no. | Abs_neuts (×109 cells/L) | %NEUT (%) | Abs_lymphs (×109 cells/L) | %LYM (%) | Abs_monos (×109 cells/L) | %MONO (%) | Abs_eos (×109 cells/L) | %EOS (%) | Abs_basos (×109 cells/L) | %BASO (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Control/♀ | 21001 | 1.01 | 24.2 | 2.93 | 69.9 | 0.13 | 3.1 | 0.08 | 1.9 | 0.01 | 0.2 |
| 0 mg/kg | 21002 | 1.12 | 31.4 | 2.27 | 63.8 | 0.07 | 1.9 | 0.07 | 2 | 0.01 | 0.4 |
| 21003 | 0.86 | 26.9 | 2.06 | 64.9 | 0.07 | 2.1 | 0.17 | 5.3 | 0 | 0.1 | |
| Mean | 1 | 27.5 | 2.42 | 66.2 | 0.09 | 2.37 | 0.11 | 3.07 | 0.01 | 0.23 | |
| SD | 0.13 | 3.6 | 0.45 | 3.3 | 0.03 | 0.64 | 0.06 | 1.93 | 0.01 | 0.15 | |
| Change (fold) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Inauhzin-C | 22001 | 1.19 | 29.6 | 2.6 | 64.9 | 0.12 | 2.9 | 0.07 | 1.8 | 0.01 | 0.1 |
| Low/♀ | 22002 | 1.06 | 25 | 2.85 | 67.3 | 0.18 | 4.1 | 0.12 | 2.7 | 0.01 | 0.2 |
| 30 mg/kg | 22003 | 1.48 | 40.5 | 1.86 | 51 | 0.14 | 3.9 | 0.13 | 3.5 | 0.01 | 0.4 |
| Mean | 1.24 | 31.7 | 2.44 | 61.1 | 0.15 | 3.63 | 0.11 | 2.67 | 0.01 | 0.23 | |
| SD | 0.22 | 8 | 0.51 | 8.8 | 0.03 | 0.64 | 0.03 | 0.85 | 0 | 0.15 | |
| Change (fold) | 1.2 | 1.2 | 1 | 0.9 | 1.6 | 1.5 | 1 | 0.9 | 1.5 | 1 | |
| Inauhzin-C | 23001 | 1.01 | 31.6 | 1.99 | 62.4 | 0.09 | 2.7 | 0.06 | 1.9 | 0.01 | 0.3 |
| Mid/♀ | 23002 | 2.36 | 45.2 | 2.51 | 48 | 0.17 | 3.3 | 0.1 | 1.9 | 0.02 | 0.4 |
| 60 mg/kg | 23003 | 1.15 | 35.3 | 1.87 | 57.4 | 0.13 | 4.1 | 0.09 | 2.6 | 0.01 | 0.3 |
| Mean | 1.51 | 37.4 | 2.12 | 55.9 | 0.13 | 3.37 | 0.08 | 2.13 | 0.01 | 0.33 | |
| SD | 0.74 | 7 | 0.34 | 7.3 | 0.04 | 0.7 | 0.02 | 0.4 | 0.01 | 0.06 | |
| Change (fold) | 1.5 | 1.4 | 0.9 | 0.8 | 1.4 | 1.4 | 0.8 | 0.7 | 2 | 1.4 | |
| Inauhzin-C | 24001 | 1.15 | 53.4 | 0.81 | 37.7 | 0.05 | 2.1 | 0.11 | 5.2 | 0.01 | 0.4 |
| High/♀ | 24002 | 2.51 | 39.9 | 3.55 | 56.5 | 0.06 | 1 | 0.08 | 1.2 | 0.03 | 0.4 |
| 120 mg/kg | 24003 | 1.04 | 44.7 | 1.15 | 49.3 | 0.04 | 1.5 | 0.06 | 2.7 | 0.01 | 0.5 |
| Mean | 1.57 | 46 | 1.84 | 47.8 | 0.05 | 1.53 | 0.08 | 3.03 | 0.02 | 0.43 | |
| SD | 0.82 | 6.8 | 1.49 | 9.5 | 0.01 | 0.55 | 0.03 | 2.02 | 0.01 | 0.06 | |
| Change (fold) | 1.6 | 1.7 | 0.8 | 0.7 | 0.6 | 0.6 | 0.8 | 1 | 2.5 | 1.9 | |