Figure 4. LB100 enhances in vivo tumor growth delay from radiation.

(A) Mice were implanted with 1×10⁶ U251 cells on the lateral aspect of the rear leg. Tumors were randomized at 172 mm³ into four groups and treated with vehicle control, LB100 alone (1.5 mg/kg by intraperitoneal injection), radiotherapy (4 Gy/fraction × 15 treatments over 3 weeks), or combination treatment with LB100 and radiotherapy. Tumors were measured three times per week and followed until they reached at least 1,500 mm³. Volumes were calculated using the formula (L × W²) × π/2. (B) Percent survival is shown, expressed in number of days after treatment randomization.