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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2015 May 14;14(7):1728–1737. doi: 10.1158/1535-7163.MCT-14-0672

Figure 2. LTLTCa-Nrf2KD cells were more sensitive to exemestane.

Figure 2

(A and B) Western blot analysis of Nrf2, INrf2 and Nrf2 downstream proteins in MCF-7Ca, LTLTCa and LTLTCaNrf2KD cells. (C) Comparative sensitivities of MCF-7Ca, LTLTCa and LTLTCa-Nrf2KD cells to exemestane. The cells were exposed to 10% ethanol in PBS (vehicle control represented by 0 exemestane) and varying concentrations of exemestane (1, 2.5, 5.0. 10, 20, 30 μM) for 72 h and analyzed for cell survival by MTT assay. Cell survival obtained at 1 and 2.5μM has been excluded from the graph as the results were similar to those obtained from 5μM. Each data point represents a mean±S.D. from three independent experiments.