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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2015 May 6;14(7):1680–1692. doi: 10.1158/1535-7163.MCT-15-0080

Figure 1.

Figure 1

BRAF inhibition induces a significant decrease in cell volume in treated human melanoma tumors. A–B, A significant reduction in mean cytoplasmic volume is observed in the majority of biopsies of patient tumors after commencement of BRAFi therapy C, without a significant decrease in mean number of nuclei per HPF. D, The majority of cases showed a large increase in average intercellular distance after commencement of therapy. E, a significant increase in number of apoptotic nuclei was not observed in the majority of cases. *, p < 0.05; **, p < 0.01; ***, p < 0.001.