Figure 2. Loss of MCU from the adult heart does not lead to pathology at baseline or with pathologic stress stimulation.
(A) Time-course for the analyses of cardiac function in response to aging following Mcu deletion.
(B) Transverse H&E heart sections at 200X magnification.
(C) Representative electron micrographs from heart sections. Scale bar is 500 nm.
(D and F) Heart-weight normalized to body-weight ratios (HW/BW) at 18 and 52 weeks of age.
(E and G) Echocardiographic measurement of fractional shortening (FS%) at 18 and 52 weeks of age.
(H) Time course for generation of mice and analyses of cardiac function following TAC surgery.
(I) H&E-stained transverse heart sections 8 weeks after TAC surgery, at 200X magnification.
(J-L) HW/BW, (K) cardiomyocyte cross-sectional area and (L) FS% in the indicated groups of mice 8 weeks following TAC.
All values reported as mean ± SEM. *P<0.05 versus Mcufl/fl sham