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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Cancer Discov. 2015 Apr 16;5(7):740–751. doi: 10.1158/2159-8290.CD-14-1347

Figure 1. Generation and Characterization of Pten+/−Inpp4b+/− and Pten+/−Inpp4b−/− mice.

Figure 1

A. Diagram representing the structure of INPP4B, which contains an N-terminus C2 domain and a C-terminus phosphatase domain harboring the phosphatase catalytic motif CX5R. B. Schematic map of the WT Inpp4b locus (top), targeting vector (upper middle) and predicted targeted allele (lower middle) and knockout allele (bottom). C. Table depicting the observed versus the expected numbers of mice of the respective genotypes from a Pten+/−Inpp4b+/− and Inpp4b+/− cross. These values gave a χ2 of 3.26, which is lower than the critical value of 11.070 which would yield an α=0.05. Thus, we conclude that the mutants were born following Mendelian frequencies.