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HA-PEI/siRNA mediated MDR-1 and PKM-2 gene silencing in SKOV-3WT (A) and SKOV-3TR (B). Cells were treated with scramble, naked siRNA, siRNA formulated in Lipofectamine and siRNA formulated in HA-PEI/PEG nanoparticles. MDR-1 and PKM-2 expression was measured by qPCR. Data represented as a mean SD (n=3). (C) Cytotoxicity assay following single and combination therapy in SKOV-3WT (left) and SKOV-3TR cells (right).
