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In vivo PTX resistance model development: (A) qPCR studies to assess MDR-1 and PKM-2 expression (B) Immunofluorescence of tumor tissues from Pg-P and PKM-2 expression in PBS treated and PTX treated animals. (C) Schematic representation of the dosing schedule adopted to develop the SKOV-3TR mouse model followed by nanoparticle treatment. (D) Effect of the combination of paclitaxel treatment and MDR1 and PKM2 silencing on growth of SKOV3TR tumors.
