Table 2.
Percentage tumor growth inhibition and tumor volume doubling time following treatment with single or combination therapy of siRNA and PTX in SKOV-3WT tumor bearing mice. PBS – phosphate buffered saline, PTX – paclitaxel, NP – nanoparticle.
| Therapeutic groups | Tumor growth inhibition (%) | Tumor volume doubling time (days) |
|---|---|---|
| PBS | 7.4±4.8 | |
| PTX solution | 56 | 10.9±13.7 |
| Naked siMDRl | 9 | 7.7±6.6 |
| Naked siPKM2 | 5 | 7.6±3.4 |
| Scrambled HA-PEI/PEG NP | 6 | 7.6±6.5 |
| Scrambled dual targeted NP | 12 | 7.8±3.2 |
| NP-MDR1 HA-PEI/PEG NP | 59 | 11.1±5.6 |
| NP-MDR1 dual targeted NP | 49 | 10.0±3.9 |
| NP-PKM2 HA-PEI/PEG NP | 54 | 10.5±6.5 |
| NP-PKM2 dual targeted NP | 65 | 12.2±5.4 |
| NP-MDR1+PKM2 HA-PEI/PEG NP | 74 | 14.2±4.6 |
| NP-MDR1+PKM2 dual targeted NP | 82 | 17.9±8.8 |