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. Author manuscript; available in PMC: 2016 Aug 7.
Published in final edited form as: Biochem Biophys Res Commun. 2015 Jun 1;463(4):644–649. doi: 10.1016/j.bbrc.2015.05.116

Figure 4. Both JAK2 and Src kinase activity are required for maximal PRL-mediated TMX2-28 cell invasion.

Figure 4

T47D and TMX2-28 cells were serum deprived and equal amounts of cells were loaded into the upper part of the Boyden chamber coated with Matrigel with or without PP1 (0.1μM), AG490 (50μM), or both inhibitors together. The number of cells that migrated to the lower part of the chamber towards PRL (500ng/ml) (black bar) or buffer control (white bar) after 48 hours were counted in 5 randomly chosen fields and plotted. Bars represent mean ± SE. *P<0.05 for three independent experiments.