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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Ann Biomed Eng. 2015 Mar 31;43(7):1640–1653. doi: 10.1007/s10439-015-1312-9

Fig. 1.

Fig. 1

Stretch and intercalation model of axonal growth. Axons respond to overstretch through immediate lengthening and thinning. Overstretch and thinning activate mechanotransduction pathways, which trigger the creation of new material along the axon, and the axon gradually recovers its initial thickness. Intracellular mass production and transport are the rate limiting factors of axonal growth.