Figure 7.
Comparison of AF model including all five atrial factors plus impaired relaxation to measurements from patients with paroxysmal AF. (a) Pressure-time curves agreed well with invasive measurements in 23 patients immediately prior to ablation. (b) Conductance-catheter-derived volumes in same patients (Measured) were smaller than those measured directly by MRI and shown in panel (c); MRI-derived volumes were used for validation as explained in text. (c) Volume-time curves fell within one standard deviation of the average measured from MRI in 31 patients (Measured, mean±SD) throughout the cardiac cycle. (d) Regional emptying fraction (REFt) of five anatomic regions in the final AF model fell within 1 SD of the in vivo averages derived from MRI in 31 AF patients.