Figure 3.

Superposition of the substrate free triose phosphate isomerase (inset orange) on the complex (green) with an intermediate analog (stick model), using λ=0.3, reduces the RMSD from 1.1 to 0.48 Å. The parsimoniously superposed model is color- and thickness-coded as in Figure 2. NMR R_ex observations are concentrated in the loop or at proximal sites (213, 221) directly affected by the loop's conformational change.