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. Author manuscript; available in PMC: 2016 Aug 5.
Published in final edited form as: Neurosci Lett. 2015 Jan 9;601:20–29. doi: 10.1016/j.neulet.2015.01.022

Figure 1.

Figure 1

Chronic stress causes atrophy of layer V pyramidal neurons in the medial PFC. Shown is the influence of repeated restraint stress (30 min per day for 7 d) on layer V pyramidal neurons in the medial PFC. The upper panels demonstrate that effects of stress on the length and branching of apical dendrites, and the lower panels show the effects of stress on the density of spines on apical dendrites of labeled layer V neurons. Neurobiotin labeled neurons were visualized by two-photon laser scanning miscrocopy (see Liu and Aghajanian, 2008).