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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Clin Ther. 2015 Mar 29;37(4):764–782. doi: 10.1016/j.clinthera.2015.02.018

Figure 1.

Figure 1

The interaction of PD-1 and PD-L1 reduces T-lymphocyte function. APC = antigen presenting cell; CTLA = cytotoxic T-lymphocyte antigen; ITIM = immunoreceptor tyrosine-based inhibitory motif; ITSM = immunoreceptor tyrosine-based switch motif; MHC = major histocompatibility complex; P = phosphoryation site; PD = programmed cell death protein; SHP = Src homology 2 domain–containing phosphatase; TCR = T cell receptor.