Fig. 4.

Time changes in BBB permeability in the cortex and striatum following tMCAO in mice treated with saline or DMTU. a Representative of Gd-DTPA-enhanced MR images at 1, 5, and 7 h after ischemia/reperfusion in mice treated with saline and DMTU. b Area of Gd-DTPA leakage was evaluated as BBB permeability. T1-weighted images (T1WI) were acquired by spin echo multi-slice sequence before and after injection of Gd-DTPA. Data are expressed as mean ± SD (n = 3–5 for each time point). *P < 0.05, **P < 0.01, as compared with control mice