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. 2015 May 8;290(28):17154–17162. doi: 10.1074/jbc.R115.638452

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Spindle scaling. A and B, different regulation of katanin activity has been traced to make X. tropicalis spindles smaller than X. laevis spindles. TPX2 concentrations modulate the spindle architecture and lead to a concentration of MTs the poles of the X. tropicalis spindle. B and C, spindle length of the X. laevis spindle is determined by MT growth velocity, which can be modulated via XMAP215 activity. X. laevis spindles become smaller throughout development and between stage 3 and stage 8; the observed size difference can be contributed to differential regulation of kif2a.