. 2015 May 21;290(28):17535–17545. doi: 10.1074/jbc.M115.659672

TABLE 2.

Single channel properties of purified heterotetrameric WT and G4934V RyR1s

	P_o		γ_K⁺	I_Ca (+10 mm Ca trans)	P_Ca/P_K
	2 μm Ca	0.1 μm Ca	γ_K⁺	I_Ca (+10 mm Ca trans)	P_Ca/P_K
			pS	pA
Type 1 (WT)	0.30 ± 0.07 (10)	0.02 ± 0.02 (10)	764 ± 9 (10)	−2.2 ± 0.1 (10)	6.7 ± 0.1 (10)
Type 2	0.31 ± 0.13 (3)	0.07 ± 0.04 (3)	740 ± 31 (3)	−1.5 ± 0.1 (3)^a	1.7 ± 0.3 (3)^a
Type 3	0.91 ± 0.03 (6)^a	0.12 ± 0.06 (6)	772 ± 9 (6)	−2.3 ± 0.1 (6)	7.1 ± 0.1 (6)^a
Type 4	0.96 ± 0.02 (13)^a	0.90 ± 0.05 (13)^a	691 ± 11 (13)^a	−1.8 ± 0.1 (13)^a	6.1 ± 0.4 (13)
Type 5 (G4934V)	0.59 ± 0.07 (40)^a	0.59 ± 0.06 (40)^a	598 ± 55 (40)	0.1 ± 0.1 (40)^a	ND^b

^a p < 0.05 compared to WT.

^b ND, not determined.