Table 1.
rs6232 | Random-effects OR (95% CI) |
P-value |
Heterogeneity |
χ2-test for difference | No. of studies/cohorts | Sample size | ||
---|---|---|---|---|---|---|---|---|
Classical | Global | I2 (95% CI) | P-value | |||||
Ethnicity | ||||||||
White Caucasian | 1.14 (1.06–1.24) | 0.001 | 1.08 × 10−5 | 44 (7–66) | 0.015 | 0.485 | 22 | 125 579 |
East Asian | 0 | 0 | ||||||
Hispanic | 1.52 (0.65–3.55) | 0.335 | 0.182 | 67 (0–90) | 0.049 | 3 | 3679 | |
African | 0.83 (0.32–2.13) | 0.694 | 0.810 | a | 0.597 | 2 | 2026 | |
Cohort age-group | ||||||||
Child/adolescent | 1.53 (1.22–1.93) | 2.84 × 10−4 | 3.68 × 10−5 | 25 (0–68) | 0.250 | 3.00 × 10−4 | 6 | 7077 |
Adult | 1.10 (1.03–1.17) | 0.006 | 0.001 | 22 (0–54) | 0.182 | 21 | 124 207 | |
Cohort size | ||||||||
≤1000 | 1.14 (0.92–1.40) | 0.223 | 0.351 | 0 (0–71) | 0.536 | 0.756 | 7 | 5983 |
>1000 | 1.16 (1.06–1.26) | 0.003 | 1.17 × 10−5 | 53 (21–72) | 0.003 | 20 | 125 301 | |
Population-based recruitment | ||||||||
No | 1.19 (1.02–1.38) | 0.030 | 7.15 × 10−4 | 53 (13–75) | 0.012 | 0.222 | 13 | 29 799 |
Yes | 1.12 (1.03–1.22) | 0.010 | 0.004 | 28 (0–62) | 0.157 | 14 | 101 485 | |
rs6234/rs6235 | ||||||||
Ethnicity | ||||||||
White Caucasian | 1.09 (1.04–1.14) | 2.04 × 10−4 | 4.28 × 10−9 | 64 (44–77) | 1.25 × 10−5 | 5.13 × 10−7 | 23 | 163 385 |
East Asian | 1.00 (0.98–1.03) | 0.961 | 1.00 | 22 (0–67) | 0.274 | 5 | 66 721 | |
Hispanic | 1.13 (0.99–1.27) | 0.050 | 0.103 | 0 (0–85) | 0.579 | 4 | 4711 | |
African | 1.16 (0.92–1.46) | 0.222 | 0.115 | 59 (0–86) | 0.064 | 4 | 4764 | |
Cohort age-group | ||||||||
Child/adolescent | 1.13 (1.00–1.29) | 0.053 | 5.61 × 10−4 | 68 (29–86) | 0.004 | 0.005 | 7 | 10 296 |
Adult | 1.06 (1.02–1.09) | 0.001 | 6.35 × 10−5 | 66 (49–77) | 4.19 × 10−7 | 29 | 229 285 | |
Cohort size | ||||||||
≤1000 | 1.02 (0.91–1.15) | 0.69 | 0.576 | 44 (0–77) | 0.096 | 0.439 | 7 | 6363 |
>1000 | 1.07 (1.04–1.11) | 2.56 × 10−5 | 3.48 × 10−7 | 71 (58–80) | 1.71 × 10−9 | 29 | 23 3218 | |
Population-based recruitment | ||||||||
No | 1.11 (1.05–1.17) | 1.60 × 10−4 | 3.65 × 10−6 | 76 (61–85) | 1.35 × 10−7 | 0.001 | 16 | 92 067 |
Yes | 1.05 (1.00–1.09) | 0.040 | 0.005 | 46 (8–68) | 0.014 | 20 | 14 7514 |
OR, odds ratio; CI, confidence interval.
aAnalysis not possible if <2 degrees of freedom.