Table 2. Meta-analysis of the association between 8q24 rs1447295, rs16901979 and rs6983267 polymorphisms and prostate cancer risk.

Variables	No. of individuals	No. of studies	Homozygous		Heterozygous		Recessive			Dominant		Allele
			OR (95% CI)	Phet	OR (95% CI)	Phet	OR (95% CI)	Phet		OR (95% CI)	Phet	OR (95% CI)	Phet
rs1447295 C>A (region1)
All	20184/20439	20	1.39 (1.01–1.91)	0.000	1.26 (1.09–1.45)	0.000	0.51 (0.39–0.67)	0.001		2.46 (1.89–3.20)	0.000	1.23 (1.09–1.40)	0.000
publication bias (Begg’s test)			P = 0.296		P = 0.382		P = 0.713			P = 0.277		P = 0.272
Ethnicity
Caucasion	17288/17469	10	1.35 (0.78–2.35)	0.000	1.15 (0.92–1.44)	0.000	0.48 (0.31–0.74)	0.014		4.15 (3.26–5.28)	0.000	1.18(0.97–1.43)	0.000
Asian	2264/1920	7	1.87 (1.33–2.62)	0.469	1.49 (1.30–1.70)	0.112	0.38 (0.27–0.53)	0.438		1.97 (1.47–2.62)	0.000	1.44 (1.29–1.60)	0.425
Africa-American	632/1050	3	0.82 (0.59–1.14)	0.349	0.95 (0.77–1.18)	0.411	0.91 (0.66–1.26)	0.992		0.74 (0.43–1.29)	0.001	0.92 (0.79–1.07)	0.487
Source of control
HB	4898/3906	12	1.28 (0.75–2.17)	0.000	1.12 (0.84–1.49)	0.000	0.52 (0.33–0.82)	0.001		2.07 (1.16–3.67)	0.000	1.16 (0.92–1.47)	0.000
PB	15286/16533	8	1.80 (1.52–2.13)	0.278	1.38 (1.22–1.57)	0.000	0.44 (0.37–0.52)	0.329		3.22 (2.78–3.74)	0.000	1.34 (1.21–1.50)	0.049
Score
Low	2492/2391	8	1.49 (0.74–2.99)	0.000	1.17 (0.92–1.51)	0.000	0.45 (0.25–0.81)	0.003		1.79 (1.01–3.16)	0.000	1.14 (0.82–1.58)	0.000
High	17692/18048	12	1.32 (0.92–1.91)	0.002	1.19 (0.82–1.71)	0.003	0.54 (0.39–0.74)	0.016		3.05 (2.31–4.02)	0.000	1.29 (1.14–1.46)	0.000
rs16901979 C>A (region2)
All	1850/2090	7	1.71 (1.36–2.16)	0.595	1.31 (1.12–1.53)	0.136	1.22 (0.80–1.87)	0.002		1.39 (1.20–1.61)	0.144	1.31 (1.18–1.46)	0.232
publication bias (Begg’s test)			P = 0.609		P = 0.948		P = 0.995			P = 0.854		P = 0.689
Ethnicity
Asian	714/648	3	1.41 (0.95–2.09)	0.661	1.15 (0.92–1.43)	0.134	1.65 (1.13–2.41)	0.293		1.19 (0.97–1.47)	0.179	1.17 (1.00–1.38)	0.350
Africa-American	619/1026	3	1.91 (1.44–2.55)	0.342	1.41 (1.10–1.80)	0.385	0.96 (0.54–1.71)	0.007		1.56 (1.24–1.96)	0.413	1.40 (1.21–1.62)	0.415
Source of control
HB	1850/2090	7	1.71 (1.36–2.16)	0.595	1.31 (1.12–1.53)	0.136	1.22 (0.80–1.87)	0.002		1.39 (1.20–1.61)	0.144	1.31 (1.18–1.46)	0.232
Score
Low	675/825	3	1.75 (1.22–2.51)	0.160	1.26 (0.8–1.97)	0.032	1.49 (1.08–2.05)	0.475		1.32 (0.84–2.08)	0.020	1.29 (1.10–1.52)	0.04
High	1175/1265	4	1.68 (1.25–2.27)	0.826	1.34 (1.09–1.65)	0.438	1.46 (1.13–1.89)	0.548		1.42 (1.17–1.73)	0.668	1.33 (1.16–1.53)	0.585
rs6983267 T>G (region3)
All	12233/7582	17	1.44 (1.31–1.58)	0.065	1.19 (1.10–1.29)	0.065	1.26 (1.18–1.36)	0.473		1.54 (0.93–2.57)	0.000	1.19 (1.14–1.25)	0.187
publication bias (Begg’s test)			P = 0.308		P = 0.959		P = 0.072			P = 0.749		P = 0.303
Ethnicity
Caucasion	9879/5487	9	1.47 (1.33–1.64)	0.065	1.25 (1.07–1.46)	0.027	1.27 (1.17–1.38)	0.427		1.77 (0.81–3.87)	0.000	1.21 (1.15–1.27)	0.102
Asian	1922/1580	6	1.33 (1.08–1.62)	0.166	1.07 (0.92–1.24)	0.746	1.27 (1.06–1.52)	0.201		1.35 (1.04–1.75)	0.005	1.14 (1.03–1.25)	0.283
Source of control
HB	4098/3021	11	1.68 (1.30–2.16)	0.038	1.17 (1.03–1.33)	0.141	1.38 (1.22–1.55)	0.223	1.43 (1.00–2.04)		0.000	1.24 (1.15–1.33)	0.092
PB	8135/4561	6	1.37 (1.22–1.54)	0.532	1.20 (1.09–1.33)	0.065	1.21 (1.10–1.32)	1.000	1.80 (0.63–5.11)		0.000	1.17 (1.10–1.24)	0.686
Score
Low	1698/1516	7	1.79 (1.19–2.67)	0.009	1.11 (0.94–1.30)	0.120	1.43 (1.19–1.73)	0.069		1.34 (0.98–1.84)	0.002	1.28 (1.07–1.54)	0.015
High	10535/6066	10	1.42 (1.31–1.58)	0.547	1.22 (1.11–1.33)	0.121	1.24 (1.14–1.34)	0.986		1.66 (0.79–3.51)	0.000	1.19 (1.13–1.25)	0.839

HB, Hospital based; PB, Population based. OR, Odds ratio; CI, confidence interval.