Table 3. False-positive report probability values for associations between the risk of cancer and the frequency of genotypes of 8q24 variants.
| 8q24 SNP genotype | Crude OR (95%CI) | Pa | statistical powerb | Prior probability |
||||
|---|---|---|---|---|---|---|---|---|
| 0.250 | 0.100 | 0.010 | 0.001 | 0.000 | ||||
| 8q24-rs1447295 C>A | ||||||||
| All patients | ||||||||
| Homozygous | 1.39 (1.01–1.91) | <0.0001 | 0.993 | 0.000 | 0.001 | 0.010 | 0.091 | 0.502 |
| Heterozygous | 1.26 (1.09–1.45) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Recessive | 0.51 (0.39–0.67) | <0.0001 | 0.896 | 0.000 | 0.001 | 0.011 | 0.100 | 0.527 |
| Dominant | 2.46 (1.89–3.20) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Allele comparision | 1.23 (1.09–1.40) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Ethnicity-Caucasian | ||||||||
| Recessive | 0.48 (0.31–0.74) | <0.0001 | 0.472 | 0.001 | 0.002 | 0.021 | 0.175 | 0.680 |
| Dominant | 4.15 (3.26–5.28) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Ethnicity-Asian | ||||||||
| Homozygous | 1.87 (1.33–2.62) | <0.0001 | 0.059 | 0.005 | 0.015 | 0.144 | 0.630 | 0.944 |
| Heterozygous | 1.49 (1.30–1.70) | <0.0001 | 0.986 | 0.000 | 0.001 | 0.010 | 0.092 | 0.504 |
| Recessive | 0.38 (0.27–0.53) | <0.0001 | 0.028 | 0.011 | 0.031 | 0.262 | 0.781 | 0.973 |
| Dominant | 1.97 (1.47–2.62) | <0.0001 | 0.968 | 0.000 | 0.001 | 0.010 | 0.094 | 0.508 |
| Allele comparision | 1.44 (1.29–1.60) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Source of control-HB | ||||||||
| Recessive | 0.52 (0.33–0.82) | 0.0436 | 0.948 | 0.121 | 0.293 | 0.820 | 0.979 | 0.998 |
| Dominant | 2.07 (1.16–3.67) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Source of control-PB | ||||||||
| Homozygous | 1.80 (1.52–2.13) | <0.0001 | 0.772 | 0.000 | 0.001 | 0.013 | 0.115 | 0.564 |
| Heterozygous | 1.38 (1.22–1.57) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Recessive | 0.44 (0.37–0.52) | <0.0001 | 0.440 | 0.001 | 0.002 | 0.022 | 0.185 | 0.694 |
| Dominant | 3.22 (2.78–3.74) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Allele comparision | 1.34 (1.21–1.50) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Score-Low | ||||||||
| Recessive | 0.45 (0.25–0.81) | <0.0001 | 0.114 | 0.003 | 0.008 | 0.080 | 0.467 | 0.898 |
| Dominant | 1.79 (1.01–3.16) | <0.0001 | 0.995 | 0.000 | 0.001 | 0.010 | 0.091 | 0.501 |
| Score-High | ||||||||
| Recessive | 0.54 (0.39–0.74) | <0.0001 | 0.696 | 0.000 | 0.001 | 0.014 | 0.126 | 0.590 |
| Dominant | 3.05 (2.31–4.02) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Allele comparision | 1.29 (1.14–1.46) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| 8q24-rs16901979 C>A | ||||||||
| All patients | ||||||||
| Homozygous | 1.71 (1.36–2.16) | 0.0663 | 0.995 | 0.167 | 0.375 | 0.868 | 0.985 | 0.999 |
| Heterozygous | 1.31 (1.12–1.53) | 0.3859 | 1.000 | 0.537 | 0.776 | 0.974 | 0.997 | 1.000 |
| Dominant | 1.39 (1.20–1.61) | 0.1506 | 0.999 | 0.312 | 0.576 | 0.937 | 0.993 | 0.999 |
| Allele comparision | 1.31 (1.18–1.46) | 0.0524 | 1.000 | 0.136 | 0.320 | 0.838 | 0.981 | 0.998 |
| Ethnicity-Asian | ||||||||
| Recessive | 1.65 (1.13–2.41) | 0.3859 | 0.908 | 0.560 | 0.793 | 0.977 | 0.998 | 1.000 |
| Allele comparision | 1.17 (1.00–1.38) | 0.0394 | 0.999 | 0.106 | 0.262 | 0.796 | 0.975 | 0.997 |
| Ethnicity-Africa-American | ||||||||
| Homozygous | 1.91 (1.44–2.55) | <0.0001 | 0.902 | 0.116 | 0.282 | 0.812 | 0.978 | 0.998 |
| Heterozygous | 1.41 (1.10–1.80) | 0.0028 | 0.837 | 0.010 | 0.029 | 0.249 | 0.770 | 0.971 |
| Dominant | 1.56 (1.24–1.96) | <0.0001 | 0.375 | 0.001 | 0.002 | 0.026 | 0.210 | 0.727 |
| Allele comparision | 1.40 (1.21–1.62) | <0.0001 | 0.371 | 0.001 | 0.002 | 0.026 | 0.212 | 0.730 |
| Source of control-HB | ||||||||
| All patients | ||||||||
| Homozygous | 1.71 (1.36–2.16) | 0.0663 | 0.995 | 0.167 | 0.375 | 0.868 | 0.985 | 0.999 |
| Heterozygous | 1.31 (1.12–1.53) | 0.3859 | 1.000 | 0.537 | 0.776 | 0.974 | 0.997 | 1.000 |
| Dominant | 1.39 (1.20–1.61) | 0.1506 | 1.000 | 0.311 | 0.575 | 0.937 | 0.993 | 0.999 |
| Allele comparision | 1.31 (1.18–1.46) | 0.0524 | 1.000 | 0.136 | 0.320 | 0.838 | 0.981 | 0.998 |
| Score-Low | ||||||||
| Homozygous | 1.75 (1.22–2.51) | 0.6976 | 0.993 | 0.678 | 0.863 | 0.986 | 0.999 | 1.000 |
| Recessive | 1.49 (1.08–2.05) | 0.7287 | 0.994 | 0.687 | 0.868 | 0.986 | 0.999 | 1.000 |
| Allele comparision | 1.29 (1.10–1.52) | 0.6989 | 1.000 | 0.677 | 0.863 | 0.986 | 0.999 | 1.000 |
| Score-High | ||||||||
| Homozygous | 1.68 (1.25–2.27) | 0.0297 | 0.883 | 0.092 | 0.232 | 0.769 | 0.971 | 0.997 |
| Heterozygous | 1.34 (1.09–1.65) | 0.2149 | 1.000 | 0.392 | 0.659 | 0.955 | 0.995 | 1.000 |
| Recessive | 1.46 (1.13–1.89) | 0.0551 | 0.926 | 0.151 | 0.349 | 0.855 | 0.983 | 0.998 |
| Dominant | 1.42 (1.17–1.73) | 0.0546 | 0.999 | 0.141 | 0.330 | 0.844 | 0.982 | 0.998 |
| Allele comparision | 1.33 (1.16–1.53) | 0.0131 | 1.000 | 0.038 | 0.105 | 0.565 | 0.929 | 0.992 |
| 8q24-rs6983267 T>G | ||||||||
| All patients | ||||||||
| Homozygous | 1.44 (1.31–1.58) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Heterozygous | 1.19 (1.10–1.29) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Recessive | 1.26 (1.18–1.36) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Allele comparision | 1.19 (1.14–1.25) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Ethnicity-Caucasian | ||||||||
| Homozygous | 1.47 (1.33–1.64) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Heterozygous | 1.25 (1.07–1.46) | 0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Recessive | 1.27 (1.17–1.38) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Allele comparision | 1.21 (1.15–1.27) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Ethnicity-Aasian | ||||||||
| Homozygous | 1.33 (1.08–1.62) | 0.0026 | 0.939 | 0.008 | 0.024 | 0.215 | 0.734 | 0.965 |
| Recessive | 1.27 (1.06–1.52) | 0.0048 | 0.959 | 0.015 | 0.043 | 0.331 | 0.833 | 0.980 |
| Dominant | 1.35 (1.04–1.75) | 0.0477 | 1.000 | 0.125 | 0.300 | 0.825 | 0.979 | 0.998 |
| Allele comparision | 1.14 (1.03–1.25) | 0.0038 | 1.000 | 0.011 | 0.033 | 0.273 | 0.792 | 0.974 |
| Source of control-HB | ||||||||
| Homozygous | 1.68 (1.30–2.16) | 0.001 | 1.000 | 0.003 | 0.009 | 0.090 | 0.500 | 0.909 |
| Heterozygous | 1.17 (1.03–1.33) | 0.002 | 1.000 | 0.006 | 0.018 | 0.165 | 0.666 | 0.952 |
| Recessive | 1.38 (1.22–1.55) | 0.0755 | 1.000 | 0.185 | 0.405 | 0.882 | 0.987 | 0.999 |
| Dominant | 1.43 (1.00–2.04) | 0.0004 | 1.000 | 0.001 | 0.004 | 0.038 | 0.286 | 0.800 |
| Allele comparision | 1.24 (1.15–1.33) | 0.0009 | 1.000 | 0.003 | 0.008 | 0.082 | 0.473 | 0.900 |
| Source of control-PB | ||||||||
| Homozygous | 1.37 (1.22–1.54) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Heterozygous | 1.20 (1.09–1.33) | 0.0021 | 1.000 | 0.006 | 0.019 | 0.172 | 0.677 | 0.955 |
| Recessive | 1.21 (1.10–1.32) | <0.0001 | 1.000 | 0.006 | 0.019 | 0.172 | 0.677 | 0.955 |
| Allele comparision | 1.17 (1.10–1.24) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Score-Low | ||||||||
| Homozygous | 1.79 (1.19–2.67) | 0.0008 | 0.871 | 0.003 | 0.008 | 0.083 | 0.478 | 0.902 |
| Recessive | 1.43 (1.19–1.73) | 0.0007 | 0.863 | 0.002 | 0.007 | 0.074 | 0.448 | 0.890 |
| Allele comparision | 1.28 (1.07–1.54) | 0.0016 | 1.000 | 0.005 | 0.014 | 0.137 | 0.615 | 0.941 |
| Score-High | ||||||||
| Homozygous | 1.42 (1.31–1.58) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
| Heterozygous | 1.22 (1.11–1.33) | 0.0003 | 1.000 | 0.001 | 0.003 | 0.029 | 0.231 | 0.710 |
| Recessive | 1.24 (1.14–1.34) | 0.0034 | 1.000 | 0.010 | 0.030 | 0.252 | 0.773 | 0.971 |
| Allele comparision | 1.19 (1.13–1.25) | <0.0001 | 1.000 | 0.000 | 0.001 | 0.010 | 0.091 | 0.500 |
OR, Odds ratio; CI, Confidence interval. The results in false-positive report probability analysis were in bold, if the prior probability <0.2.
aChi-square test was used to calculate the genotype frequency distributions.
bStatistical power was calculated using the number of observations in the subgroup and the OR and P values in this table.