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. Author manuscript; available in PMC: 2015 Jul 10.
Published in final edited form as: Cell. 2015 Feb 5;160(4):745–758. doi: 10.1016/j.cell.2015.01.012

Figure 2. Normalizing Hepatic Acetyl CoA Concentrations and Whole-Body Glycerol Turnover to Baseline Levels in the Hyperinsulinemic-Euglycemic Clamp Abrogates Insulin’s Ability to Suppress Hepatic Glucose Production.

Figure 2

(A) Liver acetyl CoA content.

(B) Whole-body glycerol turnover.

(C) Plasma glycerol concentrations.

(D) Glucose infusion rate.

(E) Hepatic glucose production from oxaloacetate (lower bars) and glycerol (upper bars).

(F) PC activity.

In all panels, ****p < 0.0001 versus basal, §§§§p < 0.0001 versus hyperinsulinemic-euglycemic clamp. n = 6 per group. Data are mean ± SEM. Comparisons by ANOVA with Bonferroni’s multiple comparisons test. See also Figure S2.