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. Author manuscript; available in PMC: 2015 Jul 10.
Published in final edited form as: Cell. 2015 Feb 5;160(4):745–758. doi: 10.1016/j.cell.2015.01.012

Figure 4. Four Weeks of High-Fat Feeding Increases Hepatic Glucose Production as a Result of Increased Lipolysis.

Figure 4

(A) Hepatic glucose production from oxaloacetate and glycerol. (B and C) Liver acetyl CoA and PC activity.

(D and E) Whole-body palmitate and glycerol turnover.

In (A)–(E), data are mean ± SEM of n = 6 per group. *p < 0.05, **p < 0.01, ****p < 0.0001 versus chow-fed, basal rats by the two-tailed unpaired Student’s t test.

(F) Hepatic glucose production in basal and clamped high-fat-fed adipose-specific ATGL knockout mice. (G and H) Liver acetyl CoA and PC activity.

(I and J) Whole-body palmitate and glycerol turnover.

In (F)–(J), data are mean ± SEM of n = 8 per group. ***p < 0.001, ****p < 0.0001 versus basal WT, ####p < 0.0001 versus basal ATGL knockouts by the two-tailed unpaired Student’s t test. See also Figures S4 and S5.