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. Author manuscript; available in PMC: 2015 Jul 10.
Published in final edited form as: Cell. 2015 Feb 5;160(4):745–758. doi: 10.1016/j.cell.2015.01.012

Figure 5. Increases in Plasma Interleukin-6 Concentrations Cause Hyperglycemia in High-Fat-Fed Rats.

Figure 5

(A and B) IL-6 concentrations in plasma and white adipose tissue macrophages.

(C–F) Hepatic glucose production, PC activity, liver acetyl CoA, and whole-body palmitate turn-over in high-fat-fed rats treated with an IL-6-neutralizing antibody.

(G and H) Hepatic glucose production, liver PC activity, hepatic acetyl CoA, and whole-body palmitate turnover in control rats treated with or without IL-6 or IL-6 and atglistatin (200 αmol/kg). In all panels, data are mean ± SEM of n = 6 per group. Comparisons by the two-tailed unpaired Student’s t test (A–E) or by ANOVA with Bonferroni’s multiple comparisons test (F–H). *p < 0.05, **p < 0.01, ***p < 0.001 versus controls; §§p < 0.01, §§§p < 0.001 versus chow-fed, IL-6-infused rats. See also Figure S6.