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PAE for SMT19969, vancomycin and fidaxomicin against C. difficile BI1, 630 and 5325
| Strain | Agent | PAE (h) |
||||
|---|---|---|---|---|---|---|
| 1 × MIC | 2 × MIC | 5 × MIC | 10 × MIC | 20 × MIC | ||
| BI1 | SMT19969 | 0 | 0 | 2 | 8–20 | >20 |
| vancomycin | 0 | 0 | 0 | 0 | 0 | |
| fidaxomicin | 0 | 8–20 | 8–20 | 8–20 | NE | |
| 5325 | SMT19969 | 0 | 0 | 0 | 4 | NE |
| vancomycin | 0 | 2 | 2 | 0 | 0 | |
| fidaxomicin | 8–20 | 8–20 | 8–20 | 8–20 | >20 | |
| 630 | SMT19969 | 0 | 2 | 2 | 4 | >20 |
| vancomycin | 0 | 0 | 0 | 0 | 2 | |
| fidaxomicin | 8–20 | 8–20 | 8–20 | >20 | >20 | |
NE, not established due to inconsistent growth recovery (see the text).
