| Silvestre et al. (2012) |
Lateral epicondylitis |
Level 3 |
26 |
3 months |
Laboratory technique with one centrifugation |
1 infiltration of 3 to 6 mL |
|
No |
Yes |
Yes |
Immobilisation splint for four weeks |
At 3 months, reduction in pain, improvement in Quick DASH score. Ultrasound showed disappearance of the fissure in 65% of patients and a reduction in the pathological zone and Doppler hyperaemia in 27% of subjects. |
| Omar et al. (2012) |
Lateral epicondylitis |
Level 1 |
30 |
6 weeks |
Laboratory technique with two centrifugations |
|
2x the blood concentration |
|
|
|
|
No difference with the control group (corticoids) |
| Chaudhury et al. (2013) |
Lateral epicondylitis |
Level 4 |
6 |
6 months |
Harvest Smart Prep2 |
1 infiltration of 3 mL |
|
|
|
Yes |
|
Positive changes to the ultrasound structure with a tendency towards increased vascularisation at the myotendinous junction |
| Krogh et al. (2013) |
Lateral epicondylitis |
Level 1 |
60 |
3 months |
GPS II |
1 infiltration of 3 to 3.5 mL |
8x the blood concentration (leukocyte rich) |
|
|
Yes |
Stretching and standardised physical therapy |
No difference between the 3 groups (PRP, physiological liquid and corticoids) |
| Mishra et al. (2014) |
Lateral epicondylitis |
Level 1 |
230 |
24 weeks |
GPS III |
1 infiltration of 2 to 3 mL |
5x the blood concentration (leukocyte rich) |
|
Yes |
|
|
Significant improvement in the PRP group after 24 weeks compared to the control group (local anaesthetic) |
| Rha et al. (2013) |
Rotator cuff |
Level 1 |
39 |
6 months |
Prosys PRP Platelet Concentration System |
2 infiltrations of 3 mL at 4 week intervals |
|
|
|
Yes |
Self-conducted therapy, pendular movements, cuff strengthening |
Significant improvement in the PRP group after the 2nd infiltration |
| Kesikburun et al. (2013) |
Rotator cuff |
Level 1 |
40 |
1 year |
GPS III |
1 infiltration of 5 mL |
|
No |
Yes |
Yes |
After 48h of rest, 3 weeks of physical therapy, pendular movements, stretching, posterior cuff and pectorals cuff strengthening |
No difference with the control group (physiological liquid) at one year |
| Marques de Almeida et al. (2012) |
Patellar |
Level 1 |
27 |
6 months |
Haemonetics MCS+ (cell separator) |
Gel |
1.2 x 106/mm3
|
0.8 mL of CaCl2
|
General anaesthetic |
|
|
Reduction in post-operative pain and accelerated healing under MRI |
| Gosens et al. (2012) |
Patellar |
Level 2 |
36 |
18 months |
Recover System |
1 infiltration of 3 mL |
|
Non |
Yes |
|
Stretching and eccentric physical therapy for 4 weeks |
Improvement in EVA and VISA-P scores. However, prior infiltrative or surgical treatments reduce the effectiveness of PRP |
| Rowan et al. (2013) |
Patellar |
Level 4 |
1 |
6 months |
|
1 infiltration of 2 mL |
|
|
|
Yes |
Nothing for two weeks and 50% in the third week, eccentric exercise from the 4th week onwards |
Return to prior level of fitness at 6 months |
| Filardo et al. (2013) |
Patellar |
Level 3 |
43 |
40 months on average (minimum 36 months) |
Laboratory technique with two centrifugations |
3 infiltrations of 5 mL (at two week intervals) |
|
CaCl2 (Ca2+ = 0.22mEq x dose) |
|
Yes |
12 weeks of eccentric physical therapy |
Improvement in VISA-P. Return to sport: 80% |
| Vetrano et al. (2013) |
Patellar |
Level 1 |
46 |
12 months |
MyCells Autologous Platelet Preparation System |
2 weekly infiltrations of 2 mL |
3 to 5x the blood concentration |
|
No |
Yes |
After 1 week, stretching and isometric then isotonic muscle strengthening |
Better results than with shock waves |
| Dragoo et al. (2014) |
Patellar |
Level 1 |
23 |
26 weeks |
GPS III |
1 infiltration of 6 mL |
Rich in leokocytes |
|
Yes |
Yes |
Direct eccentric physical therapy |
No difference with the control group (dry needle) at 26 weeks |
| Charousset et al. (2014) |
Patellar |
Level 4 |
28 |
3 months |
ACP |
3 weekly infiltrations of 6 mL |
|
|
No |
Yes |
Eccentric physical therapy after 24 hours |
Improvement in VISA-P, EVA and Lysholm scores. Return to sport: 75% |
| Kaux et al. (ePub) |
Patellar |
Level 3 |
20 |
26 weeks |
Com.Tec (apheresis) |
1 infiltration of 6 mL |
8.5 - 9 x 105 platelets/μL (no leukocyte) |
50μL CaCl2/mL PRP |
No |
No |
Sub-maximal eccentric physical therapy from the 2nd week post-infiltration. |
Improvement in EVA, IKDC and VISA-P. Return to sport:75% |
| van Ark et al. (2013) |
Patellar |
Level 4 |
5 |
26 weeks |
ACP |
1 infiltration of 433 x 109 platelets/L |
|
|
|
Yes |
Immobilisation 48h, Isometric exercises after 1 week, cycle ergometer after 2 weeks, squats from the 2nd week, eccentric physical therapy after 1 month. |
Improvement in VISA-P |
| Kaux et al. (2014) |
Patellar |
Level 3 |
30 |
1 year |
Com.Tec (apheresis) |
1 infiltration of 6 mL |
8.5 - 9 x 105 platelets/μL (no leukocytes) |
50μL CaCl2/mL PRP |
No |
|
Sub-maximal eccentric physical therapy from the 2nd week post-infiltration. |
Improvement in EVA, IKDC and VISA-P. |
| Silvestre et al. (2014) |
Calcaneal |
Level 3 |
32 |
3 months |
Laboratory technique with one centrifugation |
|
2.5 to 3x the blood concentration |
|
Yes |
Yes |
Rest 48h, walking with a 10-15mm heel piece. |
88% of patients asymptomatic with ultrasound improvements |
| Filardo et al. (2014) |
Calcaneal |
Level 3 |
27 |
54 months on average (30 months minimum) |
Laboratory technique with 2 centrifugations |
3 infiltrations of 5 mL (at two week intervals) |
5x the blood concentration (+concentrated leukocytes 1.2x the blood concentration) |
CaCl2 (Ca2+ = 0.22mEq x dose) |
No |
Yes |
24h cryotherapy after each infiltration. Eccentric physical therapy for 12 weeks after the 2nd infiltration. |
Improvement in VISA-A, EVA and Tegner scores. Return to sport: 80% |
| Murawski et al. (2014) |
Calcaneal |
Level 4 |
32 |
6 months |
Magellan PRP |
1 infiltration of 3 mL |
|
|
Yes |
|
Orthopaedic boot for 14 days, followed by 8 weeks of isometric physical therapy. |
78% of patients asymptomatic |
