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. 2015 Feb 6;61(3):161–168. doi: 10.1262/jrd.2014-107

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©2015 Society for Reproduction and Development

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.

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Fig. 4. — The addition of recombinant IGF1 and the inhibitor of IGF1, AG1024. (A) The graph indicates the granulosa cell proliferation of no-growth follicles. The follicles were separated into two groups, containing theca cells (–) or no theca cells (–), and cultured in a medium containing recombinant IGF1 (50 ng/ml). The numbers of samples used in this experiment were as follows: theca cell (–)/IGF1 (–), 19; theca cell (–)/IGF1 (+), 19; theca cell (+)/IGF1 (–), 51; theca cell (+)/IGF1 (+), 26. (B) The graph indicates the granulosa cell proliferation of no-growth follicles without theca cells. These follicles were cultured in a medium containing AG1024 or AG1024/recombinant IGF1 (50 or 100 ng/ml). The numbers of samples used in this experiment were as follows: AG1024l (–)/IGF1 (–), 12; AG1024 (+)/IGF1 (–), 22; AG1024l (+)/IGF1 (50), 16; AG1024 (+)/IGF1 (100), 13. (C) The graph indicated the granulosa cell proliferation of no-growth follicles containing theca cells. These follicles were cultured in a medium containing AG1024 or AG1024/recombinant IGF1 (50 or 100 ng/ml). The numbers of samples used in this experiment were as follows: AG1024l (–)/IGF1 (–), 47; AG1024 (+)/IGF1 (–), 45; AG1024l (+)/IGF1 (50), 28; AG1024 (+)/IGF1 (100), 31. Statistical significance is indicated by an asterisk (*P < 0.05, *** P < 0.001). Values are presented as means ± standard deviation.