Table 3.
31P MR Spectroscopic findings in healthy children and adolescent
Investigators | Sample | MRS | Region(s) of interest | Metabolites/findings |
---|---|---|---|---|
Boesch et al. (1989) | 33 wks – 6 yrs. (n = 40, 48 exams) healthy (25%) cerebral pathology (75%) chloral hydrate |
SV, 2.35 T | bilateral fronto-temporal regions |
|
van der Knaap et al. (1990) | 1 mo – 16 yrs. mean=5.9 yrs. (n = 41) no sedation |
SV, 1.5T | paraventricular region, predominantly WM |
|
Moss & Talagala (1997) | mean = 13.4 yrs. (n = 29) sedation not specified |
CSI, 1.5 T 3.5cm3 |
mesial frontal lobe mesial occipital lobe |
|
Hanaoka et al. (1998) | 4 mo – 13 yrs. (n = 37) sedation not specified |
SV, 2.0 T 60–90cm3 40–60cm3 |
bilateral fronto-parietal cerebrum bilateral cerebellar hemispheres |
|
Goldstein et al. (2009) | 6 – 18 yrs. (n = 105) no sedation |
CSI, 1.5 T 3 × 4.5 × 3 cm |
prefrontal cortex basal ganglia superior temporal cortex inferior parietal cortex centrum semiovale occipetal regions |
|
Abbreviations: SV, single voxel; CSI, chemical shift imaging; WM, white matter; GM, gray matter.
Note: Subjects in all studies were healthy, normally developing individuals except where noted otherwise. Findings reported in this table reflect healthy subjects only.