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. Author manuscript; available in PMC: 2015 Dec 16.
Published in final edited form as: J Am Coll Cardiol. 2015 Jun 16;65(23):2526–2537. doi: 10.1016/j.jacc.2015.03.570

FIGURE 6. Effects of miR-223 on Atherogenesis.

FIGURE 6

(A) Serum levels and (B) vascular levels of miR-223 in mice were knocked down by locked nucleic acid miRNA inhibitor for miR-223 (LN-anti-miR-223; 30 mg/kg intraperitoneally biweekly). (C) Atherosclerotic lesion areas (red color by oil red O staining) in aortas from apolipoprotein-E knockout mice treated with LN-anti-miR-223 or scramble control. (D) MicroRNA-223 inhibition by LN-anti-miR-223 significantly increased atherosclerotic lesion areas in apolipoprotein-E knockout mice with a Western diet. (E) Vascular neointimal lesion growth in miR-223 knockout mice was significantly increased compared with wild-type control mice in a model of carotid artery ligation injury. (F) Vascular neointimal formation in carotid arteries from wild-type C57BL/6 mice and miR-223 knockout mice. *p < 0.05 compared with control groups. Abbreviations as in Figures 1 and 3.