Greenwood 1989 GMB.

Methods	Trial design: Trial randomized by compound Data collected: 1984 to 1987 Length of follow‐up: from first prenatal visit until one week after delivery Frequency of follow‐up: unclear but administration was on weekly basis
Participants	Parity: all women Number: 1049 Inclusion criteria: all women in trial villages who became pregnant; some sub‐studies only followed up primigravidae Excluded: none stated
Interventions	Pyrimethamine 25 mg and dapsone 100 mg: fortnightly Placebo Given by village people employed by the project Other: no information Administration supervised: yes
Outcomes	Antenatal parasitaemia Birthweight Packed cell volume Maternal death Perinatal death Infant death
Notes	Location: The Gambia Urban/rural: urban Malaria transmission: seasonal Drug resistance: none reported Funding: Unclear For the analysis we assumed that it is individually RCT
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Once a woman had reported to a traditional birth attendant that she was pregnant, she was allocated to receive one tablet of Maloprim fortnightly or placebo and issued with a record card by an MRC field worker. Randomization was by compound." No details provided of a specific procedure used to generate allocation sequence.
Allocation concealment (selection bias)	Unclear risk	"Treatment was indicated on the record card by a pictorial representation of a coloured tablet (white for Maloprim,  pink for placebo)". Insufficient details provided.
Blinding (performance bias and detection bias) All outcomes	Low risk	Placebo tablets used.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No details provided.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	"1208 pregnancies which progressed beyond the 28th week were recorded during the 3 years of the survey. During 1049 (87%) of these pregnancies women reported to the TBA resident and received one or more doses of Maloprim or placebo." Unclear risk. Assumption is that attrition rate was 13.2% (159/1208, where 159 = 1208‐1049).
Selective reporting (reporting bias)	Low risk	No apparent risk.
Other bias	Low risk	None identified.