Morley 1964 NGA.

Methods	Trial design: Quasi‐RCT Data collected: 1957 Length of follow‐up: from first antenatal visit to delivery Frequency of follow‐up: insufficient detail (drugs given monthly)
Participants	All women Number: 429 Inclusion criteria: all pregnant women registered at dispensary Excluded: none stated
Interventions	Pyrimethamine: monthly Placebo Other: fever treated with chloroquine sulphate in both groups Administration supervised: women were given drugs during antenatal visits
Outcomes	Antenatal weight gain Fever episodes Parasitaemia Placental infection Birthweight Perinatal mortality
Notes	Location: Nigeria Urban/rural: rural (the village of Imesi) Malaria transmission: holoendemic area Drug resistance: none Funding: no information
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	"As the pregnant women were registered at the dispensary, they were given consecutive numbers and allotted to one or other of two groups. All women with even numbers were given 2 tablets (50 mg) of pyrimethamine once a month… The control group (the odd numbers) were given two tablets of placebo". Comment: not randomized.
Allocation concealment (selection bias)	Unclear risk	Insufficient detail provided.
Blinding (performance bias and detection bias) All outcomes	Low risk	Pyrimethamine and "similar tablets" placebo were used
Blinding of outcome assessment (detection bias) All outcomes	Low risk	"Blood films were examined in the hospital laboratory… The technicians did not know to which group a mother belonged." Assessors blinded.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Birthweight: data available for 93.7% (402/429 women). Incomplete data outcome for 6.3% (27/429) women: 17 stillbirths and 10 twin deliveries were excluded.
Selective reporting (reporting bias)	Low risk	No selective reporting observed.
Other bias	Low risk	None identified.