Parise 1998ii KEN.

Methods	As for Parise 1998i KEN
Participants	As for Parise 1998i KEN
Interventions	SP: monthly with treatment doses at enrolment and then monthly through 34 weeks of gestation No intermittent preventive treatment, SP given with recent history of fever or parasitaemia
Outcomes	As for Parise 1998i KEN
Notes	As for Parise 1998i KEN HIV seroprevalence: Monthly SP ‐ 23.7% (40/169); Case management ‐ 26.9% (57/212)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	"Women were systematically assigned to receive one of three regimens using a rotating assignment based on day of clinic visit." Comment: allocation was not random.
Allocation concealment (selection bias)	High risk	Allocation schedule not concealed.
Blinding (performance bias and detection bias) All outcomes	High risk	No blinding.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No details provided as to whether the outcome assessors were blinded.
Incomplete outcome data (attrition bias) All outcomes	High risk	Six hundred ninety‐nine women (34%) were lost to follow‐up. Data was not available for 34.8% (230/661) in the monthly SP and 35.9% (264/736) in the case management group.
Selective reporting (reporting bias)	Low risk	No selective reporting observed.
Other bias	Low risk	None identified.