Study	Reason for exclusion
Asa 2008 NGA	No placebo/no intervention group. Compares chloroquine with SP.
Briand 2009 BEN	No placebo/no intervention group. Compares SP with mefloquine.
Clerk 2008 GHA	No placebo/no intervention group. Compares SP with amodiaquine or amodiaquine plus SP.
Deen 2001	The study is a part of a double‐blinded, placebo‐controlled, village‐randomized malaria transmission‐reduction trial, comparing the efficacy of a single dose of artesunate and SP against placebo. However, target group is the general population (14,017 villagers). Women who were "thought that they might be pregnant", were advised not to take the study drugs. Some of them unknowingly took the drugs and their outcomes are reported. There is no specific method of randomization of the pregnant women who "accidentally" took the drugs, to ensure similarity of the groups. Also, distribution is uneven: N = 287 in the intervention group versus N =40 in the control group.
Diakite 2011 MLI	No placebo/no intervention group. Compares intermittent SP: 2 doses versus 3 doses.
Diallo 2007 MLI	No placebo/no intervention group. Compares weekly chloroquine with intermittent SP.
Dolan 1993	Trial of impregnated mosquito nets.
Filler 2006 MWI	No placebo/no intervention group. Compares intermittent SP: 2 doses versus 3 doses.
Gies 2009	Described as "a health centre randomized trial". This study evaluated the IPT‐SP uptake in a community‐based trial where health centres were randomized to one of three arms: IPT‐SP with health promotion, IPT‐SP without promotion and weekly CQ. The purpose was to assess the impact of a village‐based promotional campaign to enhance antenatal clinic (ANC) attendance.
Hamer 2007 ZMB	No placebo/no intervention group. Compares intermittent SP: 2 doses versus 3 doses
Hamilton 1972 UGA	This previously included trial was excluded in the updated version because Hamilton and his team administered iron to one of the control groups and folic acid to the other, but nothing was mentioned of iron and folates being administered to women in the intervention group (chloroquine).
Helitzer 1994	4 clinics trying different methods to achieve adherence; not randomized.
Kayentao 2005 MLI	No placebo/no intervention group. Compares weekly chloroquine with intermittent SP.
Luntamo 2010 MWI	No placebo/no intervention group. Compares intermittent SP: 2 doses versus 3 doses.
Martin 1982	Reported as randomized 100 women, but analysis is by whether women complied, and those that did not comply (37 participants) analysed as a separate group.
McDermott 1988	Started as a RCT, but discontinued when reports elsewhere noted an association between amodiaquine and agranulocytosis; trial then became an observational study with the 2 arms of the trial combined.
McGready 2001	Trial of repellent.
Menéndez 2011	Study done in the context of a randomized, double‐blind, placebo‐controlled trial of IPT‐ SP for malaria prevention (already included, Menendez 2008 MOZ).
Mutabingwa 1993 TZA	No placebo/no intervention group. Compares weekly chloroquine with daily proguanil.
Naniche 2008	Study done in the context of a randomized, double‐blind, placebo‐controlled trial of IPT‐ SP for malaria prevention (already included, Menendez 2008 MOZ).
Ouedraogo 2008 BFA	No placebo/no intervention group. Compares weekly chloroquine with intermittent SP.
Pertet 1994	Possible RCT; wrote to the authors in 1998; no response.
Randriam. 2011 MDG	No placebo/no intervention group. Compares weekly chloroquine with intermittent SP.
Schultz 1994 MWI	No placebo/no intervention group. Compares weekly chloroquine with intermittent SP.
Serra‐Casas 2010	Study is done in the context of a randomized, double‐blind, placebo‐controlled trial of IPT‐ SP for malaria prevention during pregnancy (already included, Menendez 2008 MOZ), investigating the effect of IPT‐SP on maternal and cord Immunoglobulin G (IgG) levels and comparing antibody levels between intervention groups. The study is mostly about the association between antibody levels and morbidity outcomes, and not focused on the specific outcomes included in the protocol for the review.
Shulman 1998	Study of impregnated mosquito nets.
Steketee 1996	Comparison between mefloquine and chloroquine.
Tagbor 2010	A randomized controlled non‐inferiority trial conducted in Ghana, comparing the safety and efficacy of intermittent screening and treatment (IST), a new strategy for malaria control, and treatment with SP. There were two intervention groups: SP and IST; IST and treatment with amodiaquine+artesunate (AQ+AS), versus the control group ‐ standard IPT‐SP. We excluded this study because a different strategy (not chemoprevention but early screening and treatment) was used in the intervention arm.
Thaler 2006	Study, comparing riboflavin (not an active antimalarial drug) to placebo.
Tukur 2007 NGA	No placebo/no intervention group. Compares chloroquine once only followed by weekly pyrimethamine with intermittent SP.
Valea 2010 BFA	No placebo/no intervention group. Compares intermittent SP: 2 doses versus 3 doses.